Found 4 hits Enz. Inhib. hit(s) with Target = 'Activin receptor type-1 [172-499]' and Ligand = 'BDBM451788' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451788
(US10710980, Example 20 | US10947218, Example 20)Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(10.71,-4.99,;9.18,-4.99,;8.41,-3.66,;6.86,-3.66,;6.24,-2.25,;7.01,-.92,;5.98,.23,;4.73,1.13,;4.57,-.4,;4.73,-1.93,;3.24,.37,;1.9,-.4,;.57,.37,;.57,1.91,;1.9,2.68,;3.24,1.91,;-.76,2.68,;-.76,4.22,;-2.1,4.99,;-3.43,4.22,;-4.76,4.99,;-3.43,2.68,;-2.1,1.91,;-4.76,1.91,;-6.1,2.68,;-4.76,.37,;-6.25,-.03,;-6.65,-1.51,;-8.14,-1.91,;-9.23,-.82,;-10.71,-1.22,;-8.83,.66,;-7.34,1.06,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451788
(US10710980, Example 20 | US10947218, Example 20)Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(10.71,-4.99,;9.18,-4.99,;8.41,-3.66,;6.86,-3.66,;6.24,-2.25,;7.01,-.92,;5.98,.23,;4.73,1.13,;4.57,-.4,;4.73,-1.93,;3.24,.37,;1.9,-.4,;.57,.37,;.57,1.91,;1.9,2.68,;3.24,1.91,;-.76,2.68,;-.76,4.22,;-2.1,4.99,;-3.43,4.22,;-4.76,4.99,;-3.43,2.68,;-2.1,1.91,;-4.76,1.91,;-6.1,2.68,;-4.76,.37,;-6.25,-.03,;-6.65,-1.51,;-8.14,-1.91,;-9.23,-.82,;-10.71,-1.22,;-8.83,.66,;-7.34,1.06,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451788
(US10710980, Example 20 | US10947218, Example 20)Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(10.71,-4.99,;9.18,-4.99,;8.41,-3.66,;6.86,-3.66,;6.24,-2.25,;7.01,-.92,;5.98,.23,;4.73,1.13,;4.57,-.4,;4.73,-1.93,;3.24,.37,;1.9,-.4,;.57,.37,;.57,1.91,;1.9,2.68,;3.24,1.91,;-.76,2.68,;-.76,4.22,;-2.1,4.99,;-3.43,4.22,;-4.76,4.99,;-3.43,2.68,;-2.1,1.91,;-4.76,1.91,;-6.1,2.68,;-4.76,.37,;-6.25,-.03,;-6.65,-1.51,;-8.14,-1.91,;-9.23,-.82,;-10.71,-1.22,;-8.83,.66,;-7.34,1.06,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451788
(US10710980, Example 20 | US10947218, Example 20)Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:6.6,26.29,wD:8.11,29.33,(10.71,-4.99,;9.18,-4.99,;8.41,-3.66,;6.86,-3.66,;6.24,-2.25,;7.01,-.92,;5.98,.23,;4.73,1.13,;4.57,-.4,;4.73,-1.93,;3.24,.37,;1.9,-.4,;.57,.37,;.57,1.91,;1.9,2.68,;3.24,1.91,;-.76,2.68,;-.76,4.22,;-2.1,4.99,;-3.43,4.22,;-4.76,4.99,;-3.43,2.68,;-2.1,1.91,;-4.76,1.91,;-6.1,2.68,;-4.76,.37,;-6.25,-.03,;-6.65,-1.51,;-8.14,-1.91,;-9.23,-.82,;-10.71,-1.22,;-8.83,.66,;-7.34,1.06,)| Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
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