Found 4 hits Enz. Inhib. hit(s) with Target = 'Activin receptor type-1 [172-499]' and Ligand = 'BDBM451806' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451806
(US10710980, Example 38 | US10947218, Example 38)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.7,4.87,;-3.37,4.1,;-2.03,4.87,;-.7,4.1,;-.7,2.56,;-2.03,1.79,;-3.37,2.56,;-4.7,1.79,;-6.03,2.56,;-4.7,.25,;-6.19,-.15,;-6.58,-1.64,;-8.07,-2.04,;-9.16,-.95,;-10.65,-1.35,;-8.76,.54,;-7.28,.94,;.64,1.79,;.64,.25,;1.97,-.52,;3.3,.25,;3.3,1.79,;1.97,2.56,;4.64,-.52,;4.8,1.01,;6.04,.11,;7.07,-1.04,;6.3,-2.37,;6.93,-3.78,;8.47,-3.78,;9.56,-4.87,;10.65,-3.78,;9.56,-2.69,;4.8,-2.05,)| Show InChI InChI=1S/C27H34N4O3/c28-25-24(26(33)30-22-5-7-23(32)8-6-22)9-19(11-29-25)18-1-3-20(4-2-18)27-10-21(27)13-31(16-27)12-17-14-34-15-17/h1-4,9,11,17,21-23,32H,5-8,10,12-16H2,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451806
(US10710980, Example 38 | US10947218, Example 38)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.7,4.87,;-3.37,4.1,;-2.03,4.87,;-.7,4.1,;-.7,2.56,;-2.03,1.79,;-3.37,2.56,;-4.7,1.79,;-6.03,2.56,;-4.7,.25,;-6.19,-.15,;-6.58,-1.64,;-8.07,-2.04,;-9.16,-.95,;-10.65,-1.35,;-8.76,.54,;-7.28,.94,;.64,1.79,;.64,.25,;1.97,-.52,;3.3,.25,;3.3,1.79,;1.97,2.56,;4.64,-.52,;4.8,1.01,;6.04,.11,;7.07,-1.04,;6.3,-2.37,;6.93,-3.78,;8.47,-3.78,;9.56,-4.87,;10.65,-3.78,;9.56,-2.69,;4.8,-2.05,)| Show InChI InChI=1S/C27H34N4O3/c28-25-24(26(33)30-22-5-7-23(32)8-6-22)9-19(11-29-25)18-1-3-20(4-2-18)27-10-21(27)13-31(16-27)12-17-14-34-15-17/h1-4,9,11,17,21-23,32H,5-8,10,12-16H2,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451806
(US10710980, Example 38 | US10947218, Example 38)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.7,4.87,;-3.37,4.1,;-2.03,4.87,;-.7,4.1,;-.7,2.56,;-2.03,1.79,;-3.37,2.56,;-4.7,1.79,;-6.03,2.56,;-4.7,.25,;-6.19,-.15,;-6.58,-1.64,;-8.07,-2.04,;-9.16,-.95,;-10.65,-1.35,;-8.76,.54,;-7.28,.94,;.64,1.79,;.64,.25,;1.97,-.52,;3.3,.25,;3.3,1.79,;1.97,2.56,;4.64,-.52,;4.8,1.01,;6.04,.11,;7.07,-1.04,;6.3,-2.37,;6.93,-3.78,;8.47,-3.78,;9.56,-4.87,;10.65,-3.78,;9.56,-2.69,;4.8,-2.05,)| Show InChI InChI=1S/C27H34N4O3/c28-25-24(26(33)30-22-5-7-23(32)8-6-22)9-19(11-29-25)18-1-3-20(4-2-18)27-10-21(27)13-31(16-27)12-17-14-34-15-17/h1-4,9,11,17,21-23,32H,5-8,10,12-16H2,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451806
(US10710980, Example 38 | US10947218, Example 38)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.7,4.87,;-3.37,4.1,;-2.03,4.87,;-.7,4.1,;-.7,2.56,;-2.03,1.79,;-3.37,2.56,;-4.7,1.79,;-6.03,2.56,;-4.7,.25,;-6.19,-.15,;-6.58,-1.64,;-8.07,-2.04,;-9.16,-.95,;-10.65,-1.35,;-8.76,.54,;-7.28,.94,;.64,1.79,;.64,.25,;1.97,-.52,;3.3,.25,;3.3,1.79,;1.97,2.56,;4.64,-.52,;4.8,1.01,;6.04,.11,;7.07,-1.04,;6.3,-2.37,;6.93,-3.78,;8.47,-3.78,;9.56,-4.87,;10.65,-3.78,;9.56,-2.69,;4.8,-2.05,)| Show InChI InChI=1S/C27H34N4O3/c28-25-24(26(33)30-22-5-7-23(32)8-6-22)9-19(11-29-25)18-1-3-20(4-2-18)27-10-21(27)13-31(16-27)12-17-14-34-15-17/h1-4,9,11,17,21-23,32H,5-8,10,12-16H2,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
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