Found 4 hits Enz. Inhib. hit(s) with Target = 'Activin receptor type-1 [172-499]' and Ligand = 'BDBM451819' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451819
(US10710980, Example 48 | US10947218, Example 48)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.31,4.95,;-2.98,4.18,;-1.64,4.95,;-.31,4.18,;-.31,2.64,;-1.64,1.87,;-2.98,2.64,;-4.31,1.87,;-5.64,2.64,;-4.31,.33,;-5.64,-.44,;-5.78,-1.97,;-7.17,-2.62,;-8.44,-1.74,;-9.66,-2.35,;-8.3,-.2,;-6.91,.45,;1.02,1.87,;1.02,.33,;2.36,-.44,;3.69,.33,;3.69,1.87,;2.36,2.64,;5.02,-.44,;5.19,1.1,;6.43,.19,;7.46,-.95,;6.69,-2.29,;7.46,-3.62,;8.89,-3.62,;9.66,-4.95,;5.19,-1.97,)| Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451819
(US10710980, Example 48 | US10947218, Example 48)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.31,4.95,;-2.98,4.18,;-1.64,4.95,;-.31,4.18,;-.31,2.64,;-1.64,1.87,;-2.98,2.64,;-4.31,1.87,;-5.64,2.64,;-4.31,.33,;-5.64,-.44,;-5.78,-1.97,;-7.17,-2.62,;-8.44,-1.74,;-9.66,-2.35,;-8.3,-.2,;-6.91,.45,;1.02,1.87,;1.02,.33,;2.36,-.44,;3.69,.33,;3.69,1.87,;2.36,2.64,;5.02,-.44,;5.19,1.1,;6.43,.19,;7.46,-.95,;6.69,-2.29,;7.46,-3.62,;8.89,-3.62,;9.66,-4.95,;5.19,-1.97,)| Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451819
(US10710980, Example 48 | US10947218, Example 48)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.31,4.95,;-2.98,4.18,;-1.64,4.95,;-.31,4.18,;-.31,2.64,;-1.64,1.87,;-2.98,2.64,;-4.31,1.87,;-5.64,2.64,;-4.31,.33,;-5.64,-.44,;-5.78,-1.97,;-7.17,-2.62,;-8.44,-1.74,;-9.66,-2.35,;-8.3,-.2,;-6.91,.45,;1.02,1.87,;1.02,.33,;2.36,-.44,;3.69,.33,;3.69,1.87,;2.36,2.64,;5.02,-.44,;5.19,1.1,;6.43,.19,;7.46,-.95,;6.69,-2.29,;7.46,-3.62,;8.89,-3.62,;9.66,-4.95,;5.19,-1.97,)| Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
BindingDB Entry DOI: 10.7270/Q24F1TVV |
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451819
(US10710980, Example 48 | US10947218, Example 48)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2 |r,wU:23.25,10.10,wD:13.14,25.27,(-4.31,4.95,;-2.98,4.18,;-1.64,4.95,;-.31,4.18,;-.31,2.64,;-1.64,1.87,;-2.98,2.64,;-4.31,1.87,;-5.64,2.64,;-4.31,.33,;-5.64,-.44,;-5.78,-1.97,;-7.17,-2.62,;-8.44,-1.74,;-9.66,-2.35,;-8.3,-.2,;-6.91,.45,;1.02,1.87,;1.02,.33,;2.36,-.44,;3.69,.33,;3.69,1.87,;2.36,2.64,;5.02,-.44,;5.19,1.1,;6.43,.19,;7.46,-.95,;6.69,-2.29,;7.46,-3.62,;8.89,-3.62,;9.66,-4.95,;5.19,-1.97,)| Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
BindingDB Entry DOI: 10.7270/Q2DF6V81 |
More data for this
Ligand-Target Pair | |
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