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Found 1 hit Enz. Inhib. hit(s) with Target = 'Acyl-CoA:cholesterol acyltransferase' and Ligand = 'BDBM50454946'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50454946
PNG
(CHEMBL79602)
Show SMILES CN(C)c1ccc(CN(Cc2cccc(c2)-c2cc[nH]n2)C(=O)Nc2c(F)cc(F)cc2F)cc1
Show InChI InChI=1S/C26H24F3N5O/c1-33(2)21-8-6-17(7-9-21)15-34(26(35)31-25-22(28)13-20(27)14-23(25)29)16-18-4-3-5-19(12-18)24-10-11-30-32-24/h3-14H,15-16H2,1-2H3,(H,30,32)(H,31,35)
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Similars
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomes

J Med Chem 41: 2390-410 (1998)


Article DOI: 10.1021/jm9800853
BindingDB Entry DOI: 10.7270/Q2MW2G7V
More data for this
Ligand-Target Pair