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Found 1 hit Enz. Inhib. hit(s) with Target = 'Acyl-CoA:cholesterol acyltransferase' and Ligand = 'BDBM50454948'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50454948
PNG
(CHEMBL311285)
Show SMILES Cc1cc(C)c(NC(=O)N(Cc2cccc(c2)-n2cccc2)C2CCCCCC2)c(C)c1
Show InChI InChI=1S/C28H35N3O/c1-21-17-22(2)27(23(3)18-21)29-28(32)31(25-12-6-4-5-7-13-25)20-24-11-10-14-26(19-24)30-15-8-9-16-30/h8-11,14-19,25H,4-7,12-13,20H2,1-3H3,(H,29,32)
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Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomes

J Med Chem 41: 2390-410 (1998)


Article DOI: 10.1021/jm9800853
BindingDB Entry DOI: 10.7270/Q2MW2G7V
More data for this
Ligand-Target Pair