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Found 1 hit Enz. Inhib. hit(s) with Target = 'Acyl-CoA:cholesterol acyltransferase' and Ligand = 'BDBM50454957'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50454957
PNG
(CHEMBL78643)
Show SMILES Cc1cc(C)c(NC(=O)N(Cc2ccc(cc2)-c2ccccc2)C2CCCCCC2)c(C)c1
Show InChI InChI=1S/C30H36N2O/c1-22-19-23(2)29(24(3)20-22)31-30(33)32(28-13-9-4-5-10-14-28)21-25-15-17-27(18-16-25)26-11-7-6-8-12-26/h6-8,11-12,15-20,28H,4-5,9-10,13-14,21H2,1-3H3,(H,31,33)
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Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomes

J Med Chem 41: 2390-410 (1998)


Article DOI: 10.1021/jm9800853
BindingDB Entry DOI: 10.7270/Q2MW2G7V
More data for this
Ligand-Target Pair