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Found 1 hit Enz. Inhib. hit(s) with Target = 'Acyl-CoA:cholesterol acyltransferase' and Ligand = 'BDBM50454958'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50454958
PNG
(CHEMBL79237)
Show SMILES Cc1cc(C)c(NC(=O)N(Cc2ccc(cc2)-n2ccnc2)C2CCCCCC2)c(C)c1
Show InChI InChI=1S/C27H34N4O/c1-20-16-21(2)26(22(3)17-20)29-27(32)31(25-8-6-4-5-7-9-25)18-23-10-12-24(13-11-23)30-15-14-28-19-30/h10-17,19,25H,4-9,18H2,1-3H3,(H,29,32)
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Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomes

J Med Chem 41: 2390-410 (1998)


Article DOI: 10.1021/jm9800853
BindingDB Entry DOI: 10.7270/Q2MW2G7V
More data for this
Ligand-Target Pair