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Found 1 hit Enz. Inhib. hit(s) with Target = 'Acyl-CoA:cholesterol acyltransferase' and Ligand = 'BDBM50454979'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Acyl-CoA:cholesterol acyltransferase


(Oryctolagus cuniculus)		BDBM50454979
PNG
(CHEMBL78387)
Show SMILES CSc1cc(C)nc(SC)c1NC(=O)N(Cc1ccccc1)Cc1ccc(cc1)-c1ccn(C)n1
Show InChI InChI=1S/C27H29N5OS2/c1-19-16-24(34-3)25(26(28-19)35-4)29-27(33)32(17-20-8-6-5-7-9-20)18-21-10-12-22(13-11-21)23-14-15-31(2)30-23/h5-16H,17-18H2,1-4H3,(H,29,33)
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Article
PubMed
n/an/a 29n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase (ACAT) in rabbit intestinal microsomes

J Med Chem 41: 2390-410 (1998)


Article DOI: 10.1021/jm9800853
BindingDB Entry DOI: 10.7270/Q2MW2G7V
More data for this
Ligand-Target Pair