Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acyl-protein thioesterase 1 (Rattus norvegicus) | BDBM16285 (2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of FAP (unknown origin) preincubated for 20 mins followed by Nle-Pro-AMC addition measured for 40 mins by continuous fluorescence assay | ACS Med Chem Lett 7: 498-501 (2016) Article DOI: 10.1021/acsmedchemlett.6b00027 BindingDB Entry DOI: 10.7270/Q2CN75SM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 1 (Rattus norvegicus) | BDBM16285 (2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.47E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University First Hospital Curated by ChEMBL | Assay Description Inhibition of FAP in human U87MG cells using Suc-Gly-Pro-AMC as substrate by fluorescence based assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127253 BindingDB Entry DOI: 10.7270/Q2N87FC7 | |||||||||||
More data for this Ligand-Target Pair |