Found 19 hits Enz. Inhib. hit(s) with Target = 'Adenosine receptor A3' and Ligand = 'BDBM10847' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Binding affinity for adenosine A3 receptor by displacement of specific binding of [125I]-AB-MECA in membranes from CHO-A3 cells |
Bioorg Med Chem Lett 15: 609-12 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.044 BindingDB Entry DOI: 10.7270/Q29K49QX |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Sheep) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | KEGG
UniProtKB/SwissProt
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| Article PubMed
| 9.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991)
Article DOI: 10.1007/bf00168610 BindingDB Entry DOI: 10.7270/Q22V2DMN |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Würzburg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 357: 1-9 (1998)
Article DOI: 10.1007/pl00005131 BindingDB Entry DOI: 10.7270/Q20Z71T3 |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113907 BindingDB Entry DOI: 10.7270/Q20K2DJC |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A3 receptor |
Bioorg Med Chem 18: 2195-203 (2010)
Article DOI: 10.1016/j.bmc.2010.01.072 BindingDB Entry DOI: 10.7270/Q2BZ670J |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 49: 3682-92 (2006)
Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 5.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A3 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Rattus norvegicus) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Binding affinity to rat adenosine A3 receptor |
Bioorg Med Chem 18: 2195-203 (2010)
Article DOI: 10.1016/j.bmc.2010.01.072 BindingDB Entry DOI: 10.7270/Q2BZ670J |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de M£laga
Curated by ChEMBL
| Assay Description Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in human HeLa cell membrane |
Bioorg Med Chem 18: 2081-8 (2010)
Article DOI: 10.1016/j.bmc.2010.02.014 BindingDB Entry DOI: 10.7270/Q2QZ2B2K |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human cloned adenosine A3 receptor expressed in CHO cells |
Bioorg Med Chem 16: 6086-102 (2008)
Article DOI: 10.1016/j.bmc.2008.04.039 BindingDB Entry DOI: 10.7270/Q2TQ61BG |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human cloned adenosine A3 receptor expressed in CHO cells |
J Med Chem 52: 2407-19 (2009)
Article DOI: 10.1021/jm8014876 BindingDB Entry DOI: 10.7270/Q2X63MVV |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 49: 3916-25 (2006)
Article DOI: 10.1021/jm060373w BindingDB Entry DOI: 10.7270/Q25H7FW1 |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 50: 4061-74 (2007)
Article DOI: 10.1021/jm070123v BindingDB Entry DOI: 10.7270/Q2JM29BR |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Binding affinity against human adenosine A3 receptor expressed in CHO cells by [125I]AB-MECA displacement. |
J Med Chem 47: 3580-90 (2004)
Article DOI: 10.1021/jm031136l BindingDB Entry DOI: 10.7270/Q2CV4JHH |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 48: 7932-45 (2005)
Article DOI: 10.1021/jm0504149 BindingDB Entry DOI: 10.7270/Q20V8CCR |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]-AB-MECA from human adenosine A3 receptor expressed in CHO cells. |
J Med Chem 43: 3118-24 (2000)
BindingDB Entry DOI: 10.7270/Q28S4P52 |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 8.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Binding affinity towards human adenosine A3 receptor expressed in HEK-293 cells using [125I]-AB-MECA at 1 uM |
J Med Chem 43: 1158-64 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WBG |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Rattus norvegicus) | BDBM10847
![PNG](/data/jpeg/tenK1/BindingDB_10847.png) (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to rat adenosine A3 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |