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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member B1' and Ligand = 'BDBM50006474'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aldo-keto reductase family 1 member B1


(Homo sapiens (Human))		BDBM50006474
PNG
(CHEMBL309132 | [5-Oxo-6-(5-trifluoromethyl-benzoth...)
Show SMILES OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2cccnc12
Show InChI InChI=1S/C18H11F3N4O3S/c19-18(20,21)9-3-4-13-11(6-9)23-14(29-13)8-25-17(28)10-2-1-5-22-16(10)12(24-25)7-15(26)27/h1-6H,7-8H2,(H,26,27)
PDB

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PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 41n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against aldose reductase isolated from human placenta

J Med Chem 35: 2155-62 (1992)


BindingDB Entry DOI: 10.7270/Q2KK99RR
More data for this
Ligand-Target Pair