Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Aldo-keto reductase family 1 member B1 (Rattus norvegicus) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
National Eye Institute Curated by ChEMBL | Assay Description Inhibitory activity against purified rat lens aldose reductase (RLAR) | J Med Chem 37: 787-92 (1994) BindingDB Entry DOI: 10.7270/Q2G73FCT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Rattus norvegicus) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Laboratories, Inc. Curated by ChEMBL | Assay Description In vitro inhibition of Aldose reductase (AR) from rat lens (RL) | J Med Chem 34: 3229-34 (1991) BindingDB Entry DOI: 10.7270/Q2QJ7HXM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Homo sapiens (Human)) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta. | J Med Chem 34: 108-22 (1991) BindingDB Entry DOI: 10.7270/Q2513X6H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Sus scrofa) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description In vitro inhibitory activity against aldose reductase in porcine lens. | J Med Chem 41: 4118-29 (1998) Article DOI: 10.1021/jm9802968 BindingDB Entry DOI: 10.7270/Q20V8BXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Rattus norvegicus) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrate | J Med Chem 34: 1011-8 (1991) Checked by Author BindingDB Entry DOI: 10.7270/Q2NK3FMZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Homo sapiens (Human)) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 56.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Modena e Reggio Emilia Curated by ChEMBL | Assay Description Inhibition of aldose reductase | Bioorg Med Chem 15: 7865-77 (2007) Article DOI: 10.1016/j.bmc.2007.08.019 BindingDB Entry DOI: 10.7270/Q2QR4WV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Homo sapiens (Human)) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 66.5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Eye Institute Curated by ChEMBL | Assay Description Inhibitory Activity against Human recombinant Aldose Reductase (wild type) | J Med Chem 43: 1062-70 (2000) BindingDB Entry DOI: 10.7270/Q2QZ2BPN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aldo-keto reductase family 1 member B1 (Rattus norvegicus) | BDBM50009777![]() ((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alcon Laboratories, Inc. Curated by ChEMBL | Assay Description In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK) | J Med Chem 34: 3229-34 (1991) BindingDB Entry DOI: 10.7270/Q2QJ7HXM | |||||||||||
More data for this Ligand-Target Pair |