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Found 1 hit Enz. Inhib. hit(s) with Target = 'Alkaline phosphatase, tissue-nonspecific isozyme' and Ligand = 'BDBM50464716'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))		BDBM50464716
PNG
(CHEMBL4283860)
Show SMILES COc1cccc(Nc2nn3c(nc(cc3=O)C(F)(F)F)s2)c1
Show InChI InChI=1S/C13H9F3N4O2S/c1-22-8-4-2-3-7(5-8)17-11-19-20-10(21)6-9(13(14,15)16)18-12(20)23-11/h2-6H,1H3,(H,17,19)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
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GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Universit£t Rostock

Curated by ChEMBL


Assay Description
Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by...

Eur J Med Chem 144: 116-127 (2018)


Article DOI: 10.1016/j.ejmech.2017.11.068
BindingDB Entry DOI: 10.7270/Q2W66PDP
More data for this
Ligand-Target Pair