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Found 2 hits Enz. Inhib. hit(s) with Target = 'Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor' and Ligand = 'BDBM50226312'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226312
PNG
(CHEMBL28249)
Show SMILES CSc1c(Cl)nc(nc1NC(C)C)N1CCNCC1
Show InChI InChI=1S/C12H20ClN5S/c1-8(2)15-11-9(19-3)10(13)16-12(17-11)18-6-4-14-5-7-18/h8,14H,4-7H2,1-3H3,(H,15,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
36n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity was measured as the inhibition of [3H]clonidine binding to alpha-2 adrenergic receptor of rat cortical membranes


J Med Chem 29: 1394-8 (1986)


BindingDB Entry DOI: 10.7270/Q21R6SQQ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50226312
PNG
(CHEMBL28249)
Show SMILES CSc1c(Cl)nc(nc1NC(C)C)N1CCNCC1
Show InChI InChI=1S/C12H20ClN5S/c1-8(2)15-11-9(19-3)10(13)16-12(17-11)18-6-4-14-5-7-18/h8,14H,4-7H2,1-3H3,(H,15,16,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
62n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]idazoxan binding to alpha-2 adrenergic receptor of rat cortical membranes


J Med Chem 29: 1394-8 (1986)


BindingDB Entry DOI: 10.7270/Q21R6SQQ
More data for this
Ligand-Target Pair