Found 6 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor' and Ligand = 'BDBM270171' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 56 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 56 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM270171
((1R,2S)-1-methoxy-N-(4-(4-methoxy-6-oxo-1,6-dihydr...)Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(O)ncnc1OC)c1ncc(C)cn1 |r,wU:2.1,3.3,(5.16,-3.15,;3.82,-2.38,;3.82,-.84,;2.49,-.07,;2.49,1.47,;1.15,-.84,;.38,-2.17,;1.92,-2.17,;-.18,-.07,;-1.51,-.84,;-1.99,-2.3,;-3.53,-2.3,;-4,-.84,;-5.49,-.44,;-5.89,1.05,;-7.38,1.45,;-8.47,.36,;-8.07,-1.13,;-9.16,-2.22,;-10.64,-1.82,;-6.58,-1.53,;-2.76,.07,;-2.76,1.61,;-4.09,2.38,;-5.43,1.61,;-4.09,3.92,;-2.76,4.69,;-1.42,3.92,;-1.42,2.38,;-.09,1.61,;1.24,2.38,;5.16,-.07,;6.49,-.84,;7.82,-.07,;7.82,1.47,;9.16,2.24,;6.49,2.24,;5.16,1.47,)| Show InChI InChI=1S/C22H25N9O6S/c1-12-9-23-18(24-10-12)17(36-4)13(2)38(33,34)30-22-29-28-19(14-7-6-8-15(27-14)35-3)31(22)16-20(32)25-11-26-21(16)37-5/h6-11,13,17H,1-5H3,(H,29,30)(H,25,26,32)/t13-,17-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
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