Found 4 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor' and Ligand = 'BDBM422376' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Apelin receptor
(Homo sapiens (Human)) | BDBM422376
![PNG](/data/jpeg/tenK42/BindingDB_422376.png) (5-(4- cyclopropylbenzene- sulfonyl)-1-(2,6- dimeth...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1-c1cncc(C)c1)S(=O)(=O)c1ccc(cc1)C1CC1 |(-6.18,-2.31,;-4.85,-1.54,;-3.51,-2.31,;-3.51,-3.85,;-2.18,-4.62,;-.85,-3.85,;-.85,-2.31,;.49,-1.54,;1.82,-2.31,;-2.18,-1.54,;-2.18,,;-.85,.77,;.49,,;-.85,2.31,;-2.18,3.08,;-2.18,4.62,;-3.51,2.31,;-3.51,.77,;-4.85,,;-5.62,-1.33,;-7.16,-1.33,;-7.93,,;-7.16,1.33,;-7.93,2.67,;-5.62,1.33,;.49,3.08,;-.28,4.41,;1.26,4.41,;1.98,2.68,;2.37,1.19,;3.86,.8,;4.95,1.88,;4.55,3.37,;3.06,3.77,;6.44,1.49,;7.53,.4,;7.93,1.88,)| Show InChI InChI=1S/C27H25N3O6S/c1-16-13-19(15-28-14-16)25-29-26(31)24(37(33,34)20-11-9-18(10-12-20)17-7-8-17)27(32)30(25)23-21(35-2)5-4-6-22(23)36-3/h4-6,9-15,17,32H,7-8H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description HEK293 cells stably expressing human APJ receptor were used to assess the activity of compounds. Cultured cells were detached and resuspended in the ... |
US Patent US10508104 (2019)
BindingDB Entry DOI: 10.7270/Q21838WS |
More data for this Ligand-Target Pair | |
Apelin receptor
(Mus musculus) | BDBM422376
![PNG](/data/jpeg/tenK42/BindingDB_422376.png) (5-(4- cyclopropylbenzene- sulfonyl)-1-(2,6- dimeth...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1-c1cncc(C)c1)S(=O)(=O)c1ccc(cc1)C1CC1 |(-6.18,-2.31,;-4.85,-1.54,;-3.51,-2.31,;-3.51,-3.85,;-2.18,-4.62,;-.85,-3.85,;-.85,-2.31,;.49,-1.54,;1.82,-2.31,;-2.18,-1.54,;-2.18,,;-.85,.77,;.49,,;-.85,2.31,;-2.18,3.08,;-2.18,4.62,;-3.51,2.31,;-3.51,.77,;-4.85,,;-5.62,-1.33,;-7.16,-1.33,;-7.93,,;-7.16,1.33,;-7.93,2.67,;-5.62,1.33,;.49,3.08,;-.28,4.41,;1.26,4.41,;1.98,2.68,;2.37,1.19,;3.86,.8,;4.95,1.88,;4.55,3.37,;3.06,3.77,;6.44,1.49,;7.53,.4,;7.93,1.88,)| Show InChI InChI=1S/C27H25N3O6S/c1-16-13-19(15-28-14-16)25-29-26(31)24(37(33,34)20-11-9-18(10-12-20)17-7-8-17)27(32)30(25)23-21(35-2)5-4-6-22(23)36-3/h4-6,9-15,17,32H,7-8H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM422376
![PNG](/data/jpeg/tenK42/BindingDB_422376.png) (5-(4- cyclopropylbenzene- sulfonyl)-1-(2,6- dimeth...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1-c1cncc(C)c1)S(=O)(=O)c1ccc(cc1)C1CC1 |(-6.18,-2.31,;-4.85,-1.54,;-3.51,-2.31,;-3.51,-3.85,;-2.18,-4.62,;-.85,-3.85,;-.85,-2.31,;.49,-1.54,;1.82,-2.31,;-2.18,-1.54,;-2.18,,;-.85,.77,;.49,,;-.85,2.31,;-2.18,3.08,;-2.18,4.62,;-3.51,2.31,;-3.51,.77,;-4.85,,;-5.62,-1.33,;-7.16,-1.33,;-7.93,,;-7.16,1.33,;-7.93,2.67,;-5.62,1.33,;.49,3.08,;-.28,4.41,;1.26,4.41,;1.98,2.68,;2.37,1.19,;3.86,.8,;4.95,1.88,;4.55,3.37,;3.06,3.77,;6.44,1.49,;7.53,.4,;7.93,1.88,)| Show InChI InChI=1S/C27H25N3O6S/c1-16-13-19(15-28-14-16)25-29-26(31)24(37(33,34)20-11-9-18(10-12-20)17-7-8-17)27(32)30(25)23-21(35-2)5-4-6-22(23)36-3/h4-6,9-15,17,32H,7-8H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM422376
![PNG](/data/jpeg/tenK42/BindingDB_422376.png) (5-(4- cyclopropylbenzene- sulfonyl)-1-(2,6- dimeth...)Show SMILES COc1cccc(OC)c1-n1c(O)c(c(=O)nc1-c1cncc(C)c1)S(=O)(=O)c1ccc(cc1)C1CC1 |(-6.18,-2.31,;-4.85,-1.54,;-3.51,-2.31,;-3.51,-3.85,;-2.18,-4.62,;-.85,-3.85,;-.85,-2.31,;.49,-1.54,;1.82,-2.31,;-2.18,-1.54,;-2.18,,;-.85,.77,;.49,,;-.85,2.31,;-2.18,3.08,;-2.18,4.62,;-3.51,2.31,;-3.51,.77,;-4.85,,;-5.62,-1.33,;-7.16,-1.33,;-7.93,,;-7.16,1.33,;-7.93,2.67,;-5.62,1.33,;.49,3.08,;-.28,4.41,;1.26,4.41,;1.98,2.68,;2.37,1.19,;3.86,.8,;4.95,1.88,;4.55,3.37,;3.06,3.77,;6.44,1.49,;7.53,.4,;7.93,1.88,)| Show InChI InChI=1S/C27H25N3O6S/c1-16-13-19(15-28-14-16)25-29-26(31)24(37(33,34)20-11-9-18(10-12-20)17-7-8-17)27(32)30(25)23-21(35-2)5-4-6-22(23)36-3/h4-6,9-15,17,32H,7-8H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325 BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this Ligand-Target Pair | |