Found 4 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor' and Ligand = 'BDBM50544744' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM50544744
(CHEMBL4647996)Show SMILES CCC(O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:9.9,(23.75,-9.44,;22.42,-8.67,;21.08,-9.44,;21.09,-10.98,;19.75,-8.68,;18.42,-9.45,;17.08,-8.68,;17.08,-7.14,;15.75,-9.45,;14.41,-8.69,;14.41,-7.15,;15.74,-6.37,;15.74,-4.83,;17.07,-4.07,;17.08,-2.53,;15.74,-1.76,;14.41,-2.53,;14.4,-4.07,;13.08,-9.46,;11.75,-8.69,;11.74,-7.15,;10.41,-9.46,;9.01,-8.84,;7.98,-9.98,;6.44,-9.83,;5.82,-8.43,;6.72,-7.18,;6.09,-5.77,;4.29,-8.26,;3.38,-9.51,;4,-10.92,;5.53,-11.09,;6.16,-12.49,;5.25,-13.74,;8.75,-11.32,;8.13,-12.72,;9.04,-13.96,;8.43,-15.37,;10.58,-13.79,;10.26,-10.99,)| Show InChI InChI=1S/C31H48N4O5/c1-6-24(36)19-32-29(37)17-23(16-15-22-11-8-7-9-12-22)33-31(38)25-18-26(35(34-25)20-21(2)3)30-27(39-4)13-10-14-28(30)40-5/h10,13-14,18,21-24,36H,6-9,11-12,15-17,19-20H2,1-5H3,(H,32,37)(H,33,38)/t23-,24?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description
Displacement of [125I]-apelin-13 from human APJ receptor stably expressed in CHOK1 cell membrane measured after 2 hrs by topcount scintillation count... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115237
BindingDB Entry DOI: 10.7270/Q2J67MJX |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544744
(CHEMBL4647996)Show SMILES CCC(O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:9.9,(23.75,-9.44,;22.42,-8.67,;21.08,-9.44,;21.09,-10.98,;19.75,-8.68,;18.42,-9.45,;17.08,-8.68,;17.08,-7.14,;15.75,-9.45,;14.41,-8.69,;14.41,-7.15,;15.74,-6.37,;15.74,-4.83,;17.07,-4.07,;17.08,-2.53,;15.74,-1.76,;14.41,-2.53,;14.4,-4.07,;13.08,-9.46,;11.75,-8.69,;11.74,-7.15,;10.41,-9.46,;9.01,-8.84,;7.98,-9.98,;6.44,-9.83,;5.82,-8.43,;6.72,-7.18,;6.09,-5.77,;4.29,-8.26,;3.38,-9.51,;4,-10.92,;5.53,-11.09,;6.16,-12.49,;5.25,-13.74,;8.75,-11.32,;8.13,-12.72,;9.04,-13.96,;8.43,-15.37,;10.58,-13.79,;10.26,-10.99,)| Show InChI InChI=1S/C31H48N4O5/c1-6-24(36)19-32-29(37)17-23(16-15-22-11-8-7-9-12-22)33-31(38)25-18-26(35(34-25)20-21(2)3)30-27(39-4)13-10-14-28(30)40-5/h10,13-14,18,21-24,36H,6-9,11-12,15-17,19-20H2,1-5H3,(H,32,37)(H,33,38)/t23-,24?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 113 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description
Agonist activity at human APJ receptor stably expressed in CHOK1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115237
BindingDB Entry DOI: 10.7270/Q2J67MJX |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544744
(CHEMBL4647996)Show SMILES CCC(O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:9.9,(23.75,-9.44,;22.42,-8.67,;21.08,-9.44,;21.09,-10.98,;19.75,-8.68,;18.42,-9.45,;17.08,-8.68,;17.08,-7.14,;15.75,-9.45,;14.41,-8.69,;14.41,-7.15,;15.74,-6.37,;15.74,-4.83,;17.07,-4.07,;17.08,-2.53,;15.74,-1.76,;14.41,-2.53,;14.4,-4.07,;13.08,-9.46,;11.75,-8.69,;11.74,-7.15,;10.41,-9.46,;9.01,-8.84,;7.98,-9.98,;6.44,-9.83,;5.82,-8.43,;6.72,-7.18,;6.09,-5.77,;4.29,-8.26,;3.38,-9.51,;4,-10.92,;5.53,-11.09,;6.16,-12.49,;5.25,-13.74,;8.75,-11.32,;8.13,-12.72,;9.04,-13.96,;8.43,-15.37,;10.58,-13.79,;10.26,-10.99,)| Show InChI InChI=1S/C31H48N4O5/c1-6-24(36)19-32-29(37)17-23(16-15-22-11-8-7-9-12-22)33-31(38)25-18-26(35(34-25)20-21(2)3)30-27(39-4)13-10-14-28(30)40-5/h10,13-14,18,21-24,36H,6-9,11-12,15-17,19-20H2,1-5H3,(H,32,37)(H,33,38)/t23-,24?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 118 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description
Agonist activity at human APJ receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115237
BindingDB Entry DOI: 10.7270/Q2J67MJX |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544744
(CHEMBL4647996)Show SMILES CCC(O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:9.9,(23.75,-9.44,;22.42,-8.67,;21.08,-9.44,;21.09,-10.98,;19.75,-8.68,;18.42,-9.45,;17.08,-8.68,;17.08,-7.14,;15.75,-9.45,;14.41,-8.69,;14.41,-7.15,;15.74,-6.37,;15.74,-4.83,;17.07,-4.07,;17.08,-2.53,;15.74,-1.76,;14.41,-2.53,;14.4,-4.07,;13.08,-9.46,;11.75,-8.69,;11.74,-7.15,;10.41,-9.46,;9.01,-8.84,;7.98,-9.98,;6.44,-9.83,;5.82,-8.43,;6.72,-7.18,;6.09,-5.77,;4.29,-8.26,;3.38,-9.51,;4,-10.92,;5.53,-11.09,;6.16,-12.49,;5.25,-13.74,;8.75,-11.32,;8.13,-12.72,;9.04,-13.96,;8.43,-15.37,;10.58,-13.79,;10.26,-10.99,)| Show InChI InChI=1S/C31H48N4O5/c1-6-24(36)19-32-29(37)17-23(16-15-22-11-8-7-9-12-22)33-31(38)25-18-26(35(34-25)20-21(2)3)30-27(39-4)13-10-14-28(30)40-5/h10,13-14,18,21-24,36H,6-9,11-12,15-17,19-20H2,1-5H3,(H,32,37)(H,33,38)/t23-,24?/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description
Agonist activity at human APJ receptor stably expressed in CHO cells co-expressing Galphaq16 assessed as increase in intracellular calcium mobilizati... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115237
BindingDB Entry DOI: 10.7270/Q2J67MJX |
More data for this
Ligand-Target Pair | |
Search and Browse
