Found 3 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor' and Ligand = 'BDBM50567163' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM50567163
(CHEMBL4863554)Show SMILES CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccncc1C |(53.9,-35.82,;55.23,-36.59,;56.57,-35.82,;57.9,-36.59,;59.23,-35.82,;59.24,-34.28,;60.57,-33.51,;60.56,-31.97,;61.9,-34.27,;61.91,-35.82,;63.24,-36.59,;60.57,-36.59,;60.57,-38.13,;61.9,-38.89,;63.23,-38.12,;64.57,-38.89,;61.91,-40.43,;60.57,-41.21,;59.23,-40.44,;59.23,-38.9,;57.9,-38.13,;56.57,-38.89,;63.23,-33.49,;62.45,-32.16,;64,-32.15,;64.57,-34.26,;64.57,-35.8,;65.9,-36.56,;67.24,-35.79,;67.22,-34.24,;65.89,-33.48,;68.57,-36.55,;69.89,-35.77,;71.23,-36.53,;71.24,-38.08,;69.91,-38.86,;68.58,-38.09,;67.24,-38.87,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325
BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Mus musculus) | BDBM50567163
(CHEMBL4863554)Show SMILES CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccncc1C |(53.9,-35.82,;55.23,-36.59,;56.57,-35.82,;57.9,-36.59,;59.23,-35.82,;59.24,-34.28,;60.57,-33.51,;60.56,-31.97,;61.9,-34.27,;61.91,-35.82,;63.24,-36.59,;60.57,-36.59,;60.57,-38.13,;61.9,-38.89,;63.23,-38.12,;64.57,-38.89,;61.91,-40.43,;60.57,-41.21,;59.23,-40.44,;59.23,-38.9,;57.9,-38.13,;56.57,-38.89,;63.23,-33.49,;62.45,-32.16,;64,-32.15,;64.57,-34.26,;64.57,-35.8,;65.9,-36.56,;67.24,-35.79,;67.22,-34.24,;65.89,-33.48,;68.57,-36.55,;69.89,-35.77,;71.23,-36.53,;71.24,-38.08,;69.91,-38.86,;68.58,-38.09,;67.24,-38.87,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325
BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50567163
(CHEMBL4863554)Show SMILES CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccncc1C |(53.9,-35.82,;55.23,-36.59,;56.57,-35.82,;57.9,-36.59,;59.23,-35.82,;59.24,-34.28,;60.57,-33.51,;60.56,-31.97,;61.9,-34.27,;61.91,-35.82,;63.24,-36.59,;60.57,-36.59,;60.57,-38.13,;61.9,-38.89,;63.23,-38.12,;64.57,-38.89,;61.91,-40.43,;60.57,-41.21,;59.23,-40.44,;59.23,-38.9,;57.9,-38.13,;56.57,-38.89,;63.23,-33.49,;62.45,-32.16,;64,-32.15,;64.57,-34.26,;64.57,-35.8,;65.9,-36.56,;67.24,-35.79,;67.22,-34.24,;65.89,-33.48,;68.57,-36.55,;69.89,-35.77,;71.23,-36.53,;71.24,-38.08,;69.91,-38.86,;68.58,-38.09,;67.24,-38.87,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325
BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this
Ligand-Target Pair | |
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