Found 3 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor' and Ligand = 'BDBM50567166' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM50567166
(CHEMBL4850182)Show SMILES CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-n1ccccc1=O |(54.82,-54.94,;56.15,-55.71,;57.48,-54.94,;58.82,-55.7,;60.15,-54.94,;60.15,-53.4,;61.48,-52.63,;61.48,-51.09,;62.82,-53.39,;62.82,-54.94,;64.16,-55.71,;61.48,-55.71,;61.49,-57.25,;62.82,-58.01,;64.15,-57.24,;65.48,-58.01,;62.82,-59.55,;61.48,-60.33,;60.15,-59.55,;60.15,-58.02,;58.82,-57.24,;57.48,-58.01,;64.15,-52.61,;63.37,-51.27,;64.91,-51.27,;65.48,-53.38,;65.48,-54.91,;66.82,-55.68,;68.15,-54.9,;68.14,-53.36,;66.8,-52.6,;69.49,-55.67,;69.49,-57.21,;70.83,-57.97,;72.16,-57.2,;72.15,-55.65,;70.81,-54.89,;70.8,-53.35,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325
BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Mus musculus) | BDBM50567166
(CHEMBL4850182)Show SMILES CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-n1ccccc1=O |(54.82,-54.94,;56.15,-55.71,;57.48,-54.94,;58.82,-55.7,;60.15,-54.94,;60.15,-53.4,;61.48,-52.63,;61.48,-51.09,;62.82,-53.39,;62.82,-54.94,;64.16,-55.71,;61.48,-55.71,;61.49,-57.25,;62.82,-58.01,;64.15,-57.24,;65.48,-58.01,;62.82,-59.55,;61.48,-60.33,;60.15,-59.55,;60.15,-58.02,;58.82,-57.24,;57.48,-58.01,;64.15,-52.61,;63.37,-51.27,;64.91,-51.27,;65.48,-53.38,;65.48,-54.91,;66.82,-55.68,;68.15,-54.9,;68.14,-53.36,;66.8,-52.6,;69.49,-55.67,;69.49,-57.21,;70.83,-57.97,;72.16,-57.2,;72.15,-55.65,;70.81,-54.89,;70.8,-53.35,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325
BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50567166
(CHEMBL4850182)Show SMILES CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-n1ccccc1=O |(54.82,-54.94,;56.15,-55.71,;57.48,-54.94,;58.82,-55.7,;60.15,-54.94,;60.15,-53.4,;61.48,-52.63,;61.48,-51.09,;62.82,-53.39,;62.82,-54.94,;64.16,-55.71,;61.48,-55.71,;61.49,-57.25,;62.82,-58.01,;64.15,-57.24,;65.48,-58.01,;62.82,-59.55,;61.48,-60.33,;60.15,-59.55,;60.15,-58.02,;58.82,-57.24,;57.48,-58.01,;64.15,-52.61,;63.37,-51.27,;64.91,-51.27,;65.48,-53.38,;65.48,-54.91,;66.82,-55.68,;68.15,-54.9,;68.14,-53.36,;66.8,-52.6,;69.49,-55.67,;69.49,-57.21,;70.83,-57.97,;72.16,-57.2,;72.15,-55.65,;70.81,-54.89,;70.8,-53.35,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at rat APJ receptor assessed as effect on cAMP accumulation by cAMP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128325
BindingDB Entry DOI: 10.7270/Q2KD22N4 |
More data for this
Ligand-Target Pair | |
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