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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Apolipoprotein L1' and Ligand = 'BDBM50547878'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apolipoprotein L1


(Homo sapiens)
BDBM50547878
PNG
(CHEMBL4752052 | US20230271945, Compound 61)
Show SMILES O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2c(F)cccc12)-c1ccccc1 |r|
PDB

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KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a<250n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of APOL1 (unknown origin) in HEK293 cells assessed as thallium influx incubated for 30 mins by FLIPR based thallium influx assay


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00531
BindingDB Entry DOI: 10.7270/Q25Q50QQ
More data for this
Ligand-Target Pair
Apolipoprotein L1


(Homo sapiens)
BDBM50547878
PNG
(CHEMBL4752052 | US20230271945, Compound 61)
Show SMILES O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2c(F)cccc12)-c1ccccc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent




US Patent US9725441 (2017)


BindingDB Entry DOI: 10.7270/Q2FJ2MXG
More data for this
Ligand-Target Pair
Apolipoprotein L1


(Homo sapiens)
BDBM50547878
PNG
(CHEMBL4752052 | US20230271945, Compound 61)
Show SMILES O[C@@H]1CNC(=O)[C@H]1NC(=O)CCc1c([nH]c2c(F)cccc12)-c1ccccc1 |r|
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 600n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent




US Patent US9725441 (2017)


BindingDB Entry DOI: 10.7270/Q2FJ2MXG
More data for this
Ligand-Target Pair