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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM156389'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM156389
PNG
(US9018381, 12 | US9248140, 12)
Show SMILES CCN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](N)c1ccccc1-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C46H51ClF3N5O6S3/c1-2-54(28-29-56)25-24-36(31-62-38-8-4-3-5-9-38)52-42-21-20-39(30-43(42)63(58,59)46(48,49)50)64(60,61)53-45(57)34-14-18-37(19-15-34)55-26-22-33(23-27-55)44(51)41-11-7-6-10-40(41)32-12-16-35(47)17-13-32/h3-21,30,33,36,44,52,56H,2,22-29,31,51H2,1H3,(H,53,57)/t36-,44-/m1/s1
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Similars
US Patent
n/an/a 3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
Bcl-xL and Bcl-2 FP binding affinity of compound(s) of Formulae (I), (I-a), (I-b), (I-c), (I-d) and/or (I-e) may be determined using a variety of kno...

US Patent US9018381 (2015)


BindingDB Entry DOI: 10.7270/Q2BC3X8D
More data for this
Ligand-Target Pair