Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177803'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177803 (US9120791, Example 21 | US9603854, 21) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc2NCCc2c1 Show InChI InChI=1S/C44H44ClN5O4/c45-32-8-14-37(43(52)49-27-31-6-2-1-5-29(31)23-35(49)28-47-19-21-54-22-20-47)38(25-32)42-26-39(41-7-3-4-18-48(41)42)44(53)50(33-9-12-36(51)13-10-33)34-11-15-40-30(24-34)16-17-46-40/h1-2,5-6,8-15,24-26,35,46,51H,3-4,7,16-23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177803 (US9120791, Example 21 | US9603854, 21) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccc2NCCc2c1 Show InChI InChI=1S/C44H44ClN5O4/c45-32-8-14-37(43(52)49-27-31-6-2-1-5-29(31)23-35(49)28-47-19-21-54-22-20-47)38(25-32)42-26-39(41-7-3-4-18-48(41)42)44(53)50(33-9-12-36(51)13-10-33)34-11-15-40-30(24-34)16-17-46-40/h1-2,5-6,8-15,24-26,35,46,51H,3-4,7,16-23,27-28H2/t35-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair