Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177867'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177867 (US9120791, Example 92 | US9603854, 92) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41FN4O7/c1-27-6-7-31(19-37(27)44)48(30-8-10-33(49)11-9-30)43(51)36-20-38(46-14-17-53-25-39(36)46)34-21-40-41(55-26-54-40)22-35(34)42(50)47-23-29-5-3-2-4-28(29)18-32(47)24-45-12-15-52-16-13-45/h2-11,19-22,32,49H,12-18,23-26H2,1H3/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177867 (US9120791, Example 92 | US9603854, 92) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41FN4O7/c1-27-6-7-31(19-37(27)44)48(30-8-10-33(49)11-9-30)43(51)36-20-38(46-14-17-53-25-39(36)46)34-21-40-41(55-26-54-40)22-35(34)42(50)47-23-29-5-3-2-4-28(29)18-32(47)24-45-12-15-52-16-13-45/h2-11,19-22,32,49H,12-18,23-26H2,1H3/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair