Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177898'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177898 (US9120791, Example 128 | US9603854, 128) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1=O Show InChI InChI=1S/C44H43N5O6/c1-45-19-20-46(27-42(45)51)26-33-21-29-9-5-6-10-30(29)25-48(33)43(52)36-24-41-40(54-28-55-41)23-35(36)39-22-37(38-13-7-8-18-47(38)39)44(53)49(31-11-3-2-4-12-31)32-14-16-34(50)17-15-32/h2-6,9-12,14-17,22-24,33,50H,7-8,13,18-21,25-28H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177898 (US9120791, Example 128 | US9603854, 128) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1=O Show InChI InChI=1S/C44H43N5O6/c1-45-19-20-46(27-42(45)51)26-33-21-29-9-5-6-10-30(29)25-48(33)43(52)36-24-41-40(54-28-55-41)23-35(36)39-22-37(38-13-7-8-18-47(38)39)44(53)49(31-11-3-2-4-12-31)32-14-16-34(50)17-15-32/h2-6,9-12,14-17,22-24,33,50H,7-8,13,18-21,25-28H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair