Found 3 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM356777' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM356777
![PNG](/data/jpeg/tenK35/BindingDB_356777.png) (4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e...)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC[C@@H]4CC[C@H](O)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-13-32(39(25-45)30-4-6-33(46)7-5-30)28-51-17-19-52(20-18-51)34-8-11-38(42(23-34)60-36-22-31-14-16-47-43(31)49-27-36)44(55)50-61(58,59)37-10-12-40(41(24-37)53(56)57)48-26-29-3-9-35(54)21-29/h4-8,10-12,14,16,22-24,27,29,35,48,54H,3,9,13,15,17-21,25-26,28H2,1-2H3,(H,47,49)(H,50,55)/t29-,35+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc.
US Patent
| Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay. |
US Patent US10213433 (2019)
BindingDB Entry DOI: 10.7270/Q23F4RZ6 |
More data for this Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM356777
![PNG](/data/jpeg/tenK35/BindingDB_356777.png) (4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e...)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC[C@@H]4CC[C@H](O)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-13-32(39(25-45)30-4-6-33(46)7-5-30)28-51-17-19-52(20-18-51)34-8-11-38(42(23-34)60-36-22-31-14-16-47-43(31)49-27-36)44(55)50-61(58,59)37-10-12-40(41(24-37)53(56)57)48-26-29-3-9-35(54)21-29/h4-8,10-12,14,16,22-24,27,29,35,48,54H,3,9,13,15,17-21,25-26,28H2,1-2H3,(H,47,49)(H,50,55)/t29-,35+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM356777
![PNG](/data/jpeg/tenK35/BindingDB_356777.png) (4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-e...)Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC[C@@H]4CC[C@H](O)C4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)15-13-32(39(25-45)30-4-6-33(46)7-5-30)28-51-17-19-52(20-18-51)34-8-11-38(42(23-34)60-36-22-31-14-16-47-43(31)49-27-36)44(55)50-61(58,59)37-10-12-40(41(24-37)53(56)57)48-26-29-3-9-35(54)21-29/h4-8,10-12,14,16,22-24,27,29,35,48,54H,3,9,13,15,17-21,25-26,28H2,1-2H3,(H,47,49)(H,50,55)/t29-,35+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| <0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonan... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q21V5J59 |
More data for this Ligand-Target Pair | |