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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM50519018'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50519018
PNG
(CHEMBL4460382)
Show SMILES CCc1sc2ncnc(NC(C(O)=O)c3ccccc3)c2c1-c1cccc(Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C28H22FN3O3S/c1-2-22-23(18-9-6-10-21(15-18)35-20-13-11-19(29)12-14-20)24-26(30-16-31-27(24)36-22)32-25(28(33)34)17-7-4-3-5-8-17/h3-16,25H,2H2,1H3,(H,33,34)(H,30,31,32)
PDB

UniProtKB/SwissProt

antibodypedia
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AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 1.30E+4n/an/an/an/an/an/an/an/a



Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL


Assay Description
Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from human N-terminal thrombin cleavage site-fused/His6-tagged Bcl-2 expressed in Es...

J Med Chem 62: 6913-6924 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00134
BindingDB Entry DOI: 10.7270/Q2DZ0CPH
More data for this
Ligand-Target Pair