BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM50519029'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50519029
PNG
(CHEMBL4524567)
Show SMILES OC(=O)[C@@H](Cc1ccccc1)Nc1ncnc2sc(c(-c3cccc(O)c3)c12)-c1ccccc1 |r|
Show InChI InChI=1S/C27H21N3O3S/c31-20-13-7-12-19(15-20)22-23-25(30-21(27(32)33)14-17-8-3-1-4-9-17)28-16-29-26(23)34-24(22)18-10-5-2-6-11-18/h1-13,15-16,21,31H,14H2,(H,32,33)(H,28,29,30)/t21-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 2.10E+4n/an/an/an/an/an/an/an/a



Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL


Assay Description
Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from human N-terminal thrombin cleavage site-fused/His6-tagged Bcl-2 expressed in Es...

J Med Chem 62: 6913-6924 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00134
BindingDB Entry DOI: 10.7270/Q2DZ0CPH
More data for this
Ligand-Target Pair