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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM50519036'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50519036
PNG
(CHEMBL4467044)
Show SMILES CCc1sc2ncnc(N[C@H](C)C(O)=O)c2c1-c1cccc(Oc2ccc(F)cc2)c1 |r|
Show InChI InChI=1S/C23H20FN3O3S/c1-3-18-19(20-21(27-13(2)23(28)29)25-12-26-22(20)31-18)14-5-4-6-17(11-14)30-16-9-7-15(24)8-10-16/h4-13H,3H2,1-2H3,(H,28,29)(H,25,26,27)/t13-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
 6.10E+3n/an/an/an/an/an/an/an/a



Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL


Assay Description
Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from human N-terminal thrombin cleavage site-fused/His6-tagged Bcl-2 expressed in Es...

J Med Chem 62: 6913-6924 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00134
BindingDB Entry DOI: 10.7270/Q2DZ0CPH
More data for this
Ligand-Target Pair