BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Arginase-1' and Ligand = 'BDBM290372'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Arginase-1 (Homo sapiens (Human))	BDBM290372 ((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...) Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
New England Discovery Partners Curated by ChEMBL					Assay Description Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...				J Med Chem 62: 8164-8177 (2019) Article DOI: 10.1021/acs.jmedchem.9b00931 BindingDB Entry DOI: 10.7270/Q2X92FM9
New England Discovery Partners Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290372 ((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...) Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	113	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co., Inc. Curated by ChEMBL					Assay Description Inhibition of human arginase1 in presence of DNTB by thio ornithine generation assay				ACS Med Chem Lett 11: 582-588 (2020) Article DOI: 10.1021/acsmedchemlett.0c00058 BindingDB Entry DOI: 10.7270/Q26113VN
Merck & Co., Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290372 ((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...) Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				Citation and Details BindingDB Entry DOI: 10.7270/Q289193N
TBA					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290372 ((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...) Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	625	n/a	n/a	n/a	n/a	7.4	25
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10098902 (2018) BindingDB Entry DOI: 10.7270/Q2319XXK
Mars, Incorporated US Patent					More data for this Ligand-Target Pair
Arginase-1 (Homo sapiens (Human))	BDBM290372 ((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...) Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Mars, Incorporated US Patent					Assay Description Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...				US Patent US10603330 (2020) BindingDB Entry DOI: 10.7270/Q2WD43K6
Mars, Incorporated US Patent					More data for this Ligand-Target Pair