Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 1' and Ligand = 'BDBM209221'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209221 (US9266877, 167) Show SMILES Cc1c(cnn1CC1(CCCCC1)OCCN1CCS(=O)(=O)CC1)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C40H45N7O6S2/c1-27-31(24-41-47(27)26-40(15-5-2-6-16-40)53-21-18-45-19-22-55(51,52)23-20-45)29-12-13-35(43-36(29)38(49)50)46-17-14-28-8-7-9-30(32(28)25-46)37(48)44-39-42-33-10-3-4-11-34(33)54-39/h3-4,7-13,24H,2,5-6,14-23,25-26H2,1H3,(H,49,50)(H,42,44,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	<-57.1	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Mus musculus (Mouse))	BDBM209221 (US9266877, 167) Show SMILES Cc1c(cnn1CC1(CCCCC1)OCCN1CCS(=O)(=O)CC1)-c1ccc(nc1C(O)=O)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C40H45N7O6S2/c1-27-31(24-41-47(27)26-40(15-5-2-6-16-40)53-21-18-45-19-22-55(51,52)23-20-45)29-12-13-35(43-36(29)38(49)50)46-17-14-28-8-7-9-30(32(28)25-46)37(48)44-39-42-33-10-3-4-11-34(33)54-39/h3-4,7-13,24H,2,5-6,14-23,25-26H2,1H3,(H,49,50)(H,42,44,48)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	81	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair