Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]' and Ligand = 'BDBM471543'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM471543 (US10821115, Example 100560 | US11224601, Example 1...) Show SMILES CO[C@@]1(Cc2cc(C)ccn2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:12| Show InChI InChI=1S/C40H48ClN3O5S/c1-26-15-18-42-33(19-26)22-40(48-4)17-5-7-27(2)28(3)50(46,47)43-38(45)30-10-14-37-36(21-30)44(23-31-9-12-35(31)40)24-39(25-49-37)16-6-8-29-20-32(41)11-13-34(29)39/h5,10-11,13-15,17-21,27-28,31,35H,6-9,12,16,22-25H2,1-4H3,(H,43,45)/b17-5+/t27-,28+,31-,35+,39-,40+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...				Citation and Details BindingDB Entry DOI: 10.7270/Q2WH2T5S
					More data for this Ligand-Target Pair