Found 28 hits Enz. Inhib. hit(s) with Target = 'Beta-3 adrenergic receptor' and Ligand = 'BDBM25392' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Würzburg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 369: 151-9 (2004)
Article DOI: 10.1007/s00210-003-0860-y BindingDB Entry DOI: 10.7270/Q2PZ57C6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| 1.86E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee
Curated by ChEMBL
| Assay Description Binding Affinity against human Beta-3 adrenergic receptor expressed in Chinese hamster ovary(CHO) cells was measured by using [125I]ICYP radioligand |
J Med Chem 42: 2287-94 (1999)
Article DOI: 10.1021/jm990012z BindingDB Entry DOI: 10.7270/Q2057JN4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP production |
J Med Chem 49: 2758-71 (2006)
Checked by Author Article DOI: 10.1021/jm0509445 BindingDB Entry DOI: 10.7270/Q2KD20D5 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-ga... |
J Med Chem 52: 2280-8 (2009)
Article DOI: 10.1021/jm801016j BindingDB Entry DOI: 10.7270/Q2ST7R2P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Fujisawa Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Agonistic activity was assessed by measuring cAMP accumulation in CHO cell lines expressing cloned human Beta-3 adrenergic receptor |
Bioorg Med Chem Lett 15: 251-4 (2004)
Article DOI: 10.1016/j.bmcl.2004.11.001 BindingDB Entry DOI: 10.7270/Q2QJ7J2T |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB PubMed
| n/a | n/a | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activity against human beta 3 adrenergic receptor (AR), expressed in CHO cells. |
J Med Chem 45: 567-83 (2002)
BindingDB Entry DOI: 10.7270/Q2W0976P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 86 | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant beta3-adrenergic receptor expressed in CHO cells assessed as increase of cAMP level after 30 mins |
J Med Chem 58: 6048-57 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00638 BindingDB Entry DOI: 10.7270/Q2NG4SDR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immuno assay |
J Med Chem 51: 4002-20 (2008)
Article DOI: 10.1021/jm8000345 BindingDB Entry DOI: 10.7270/Q2MS3SKD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem Lett 18: 5037-40 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.009 BindingDB Entry DOI: 10.7270/Q21R6QBZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc
Curated by ChEMBL
| Assay Description Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem 17: 3283-94 (2009)
Article DOI: 10.1016/j.bmc.2009.03.044 BindingDB Entry DOI: 10.7270/Q2PG1RM6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by enzyme immunoassay |
J Med Chem 52: 3063-72 (2009)
Article DOI: 10.1021/jm9000709 BindingDB Entry DOI: 10.7270/Q2S75G6J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist efficacy for human Beta-3 adrenergic receptor expressed in chinese hamster ovary cells |
Bioorg Med Chem Lett 7: 219-224 (1997)
Article DOI: 10.1016/S0960-894X(96)00603-8 BindingDB Entry DOI: 10.7270/Q2QZ2BFH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 87 | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd.
Curated by ChEMBL
| Assay Description Concentration required to effect a 50% relaxation of rat ferret detrusor basal tone |
J Med Chem 46: 105-12 (2002)
Article DOI: 10.1021/jm020177z BindingDB Entry DOI: 10.7270/Q2BP03J1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation by EIA |
J Med Chem 51: 1925-44 (2008)
Article DOI: 10.1021/jm701324c BindingDB Entry DOI: 10.7270/Q24X58PB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem 19: 4192-201 (2011)
Article DOI: 10.1016/j.bmc.2011.05.064 BindingDB Entry DOI: 10.7270/Q2BK1DM0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description Agonist activity at human beta3 receptor expressed in CHO cells assessed as cAMP accumulation |
Bioorg Med Chem 19: 6026-32 (2011)
Article DOI: 10.1016/j.bmc.2011.08.043 BindingDB Entry DOI: 10.7270/Q2DB833D |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant adrenergic beta3 receptor expressed in CHO cells assessed as stimulation of cAMP level after 1 hr by enzyme imm... |
Bioorg Med Chem Lett 19: 4679-83 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.083 BindingDB Entry DOI: 10.7270/Q2S183DR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 0.970 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc
Curated by ChEMBL
| Assay Description Agonist activity at human cloned beta3 adrenergic receptor expressed in CHO cells assessed as cAMP accumulation |
J Med Chem 51: 4804-22 (2008)
Article DOI: 10.1021/jm800222k BindingDB Entry DOI: 10.7270/Q25D8SQ8 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
Universit£ di Bari
Curated by ChEMBL
| Assay Description Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as [3H]cAMP levels by radiolabeled ligand based assay |
Bioorg Med Chem 16: 2473-88 (2008)
Article DOI: 10.1016/j.bmc.2007.11.060 BindingDB Entry DOI: 10.7270/Q2TD9Z7B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as increase in cAMP production after 2 days by radioimmuno... |
Eur J Med Chem 44: 2533-43 (2009)
Article DOI: 10.1016/j.ejmech.2009.01.022 BindingDB Entry DOI: 10.7270/Q2JM2BJV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassa... |
Bioorg Med Chem 17: 5510-9 (2009)
Checked by Author Article DOI: 10.1016/j.bmc.2009.06.031 BindingDB Entry DOI: 10.7270/Q23F4QKV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human cloned adrenergic beta3 receptor expressed in CHO cells assessed as [125I]cAMP accumulation after 2 days by radioimmunoassa... |
Bioorg Med Chem 17: 5510-9 (2009)
Checked by Author Article DOI: 10.1016/j.bmc.2009.06.031 BindingDB Entry DOI: 10.7270/Q23F4QKV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Rattus norvegicus) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
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| PubMed
| n/a | n/a | n/a | n/a | 87.1 | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd.
Curated by ChEMBL
| Assay Description Agonistic activity towards beta-3 adrenoceptor. EC50, the mean concentration required to produce 50% relaxation of detrusor before the addition in th... |
J Med Chem 44: 1436-45 (2001)
BindingDB Entry DOI: 10.7270/Q2Q52QVH |
More data for this Ligand-Target Pair | |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description Agonist activity at human recombinant beta3 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after... |
J Med Chem 53: 4522-30 (2010)
Article DOI: 10.1021/jm100326d BindingDB Entry DOI: 10.7270/Q23N24N1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 86 | n/a | n/a | n/a | n/a |
Asahi Kasei Pharma Corporation
Curated by ChEMBL
| Assay Description Agonist activity at recombinant human beta3 adrenergic receptor expressed in CHO cells assessed as accumulation of cyclic AMP after 30 mins |
J Med Chem 60: 3252-3265 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01197 BindingDB Entry DOI: 10.7270/Q2M61NQX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
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| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a |
Universit£ di Bari
Curated by ChEMBL
| Assay Description Agonist activity at human adrenergic beta-3 receptor expressed in CHO cells assessed as cAMP levels by DELFIA method |
Bioorg Med Chem 16: 2473-88 (2008)
Article DOI: 10.1016/j.bmc.2007.11.060 BindingDB Entry DOI: 10.7270/Q2TD9Z7B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Homo sapiens (Human)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | n/a | n/a | 54 | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Agonist activity at human beta3 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay |
Eur J Med Chem 152: 424-435 (2018)
Article DOI: 10.1016/j.ejmech.2018.04.041 BindingDB Entry DOI: 10.7270/Q2GH9MNH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Beta-3 adrenergic receptor
(Rattus norvegicus) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
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| PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
American Cyanamid Company
Curated by ChEMBL
| Assay Description Compound was evaluated in vitro for beta adrenergic receptor activity against beta-3 adrenergic receptor in rat epididymal fat pads by stimulation of... |
J Med Chem 35: 3081-4 (1992)
BindingDB Entry DOI: 10.7270/Q2PR7TWN |
More data for this Ligand-Target Pair | |