Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM148179'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM148179 (US8962616, 7) Show SMILES CC1N=CC(=N1)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:2,4,13| Show InChI InChI=1S/C17H18F2N4OS/c1-9-21-6-14(22-9)15-4-10-7-25-16(20)23-17(10,8-24-15)12-3-2-11(18)5-13(12)19/h2-3,5-6,9-10,15H,4,7-8H2,1H3,(H2,20,23)/t9?,10?,15-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	185	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
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