Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM148186'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM148186 (US8962616, 15) Show SMILES Cc1nc(oc1C)[C@H]1CC2CSC(N)=N[C@]2(CO1)c1ccc(F)cc1F |c:14| Show InChI InChI=1S/C18H19F2N3O2S/c1-9-10(2)25-16(22-9)15-5-11-7-26-17(21)23-18(11,8-24-15)13-4-3-12(19)6-14(13)20/h3-4,6,11,15H,5,7-8H2,1-2H3,(H2,21,23)/t11?,15-,18+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.82E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
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