Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM148189'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM148189 (US8962616, 20) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1nc(co1)C(F)(F)F)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H14F5N3O2S/c18-9-1-2-10(11(19)4-9)16-7-27-12(3-8(16)6-28-15(23)25-16)14-24-13(5-26-14)17(20,21)22/h1-2,4-5,8,12H,3,6-7H2,(H2,23,25)/t8-,12+,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	629	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
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