Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM148190'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM148190 (US8962616, 21) Show SMILES NC1=N[C@]2(CO[C@H](C[C@H]2CS1)c1ncccn1)c1ccc(F)cc1F |r,t:1| Show InChI InChI=1S/C17H16F2N4OS/c18-11-2-3-12(13(19)7-11)17-9-24-14(15-21-4-1-5-22-15)6-10(17)8-25-16(20)23-17/h1-5,7,10,14H,6,8-9H2,(H2,20,23)/t10-,14+,17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a	4.5	37
Pfizer Inc. US Patent					Assay Description This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...				US Patent US8962616 (2015) BindingDB Entry DOI: 10.7270/Q20Z7216
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