Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM190753'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM190753 (US9181236, 51) Show SMILES C[C@]1(CS(=O)(=O)C2(CCOCC2)C(=N)N1)c1sc(cc1Cl)-c1cncnc1 |r| Show InChI InChI=1S/C17H19ClN4O3S2/c1-16(14-12(18)6-13(26-14)11-7-20-10-21-8-11)9-27(23,24)17(15(19)22-16)2-4-25-5-3-17/h6-8,10H,2-5,9H2,1H3,(H2,19,22)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<100	<-40.6	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISE...				US Patent US9181236 (2015) BindingDB Entry DOI: 10.7270/Q2NC5ZZB
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