Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM259205'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 2 (Homo sapiens (Human))	BDBM259205 (US9499502, 30b) Show SMILES C[C@]1(CS(=O)(=O)C(C)(C)C(=N)N1)c1cc(Nc2noc3cc(F)cnc23)ccc1F |r| Show InChI InChI=1S/C19H19F2N5O3S/c1-18(2)17(22)25-19(3,9-30(18,27)28)12-7-11(4-5-13(12)21)24-16-15-14(29-26-16)6-10(20)8-23-15/h4-8H,9H2,1-3H3,(H2,22,25)(H,24,26)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	-48.2	n/a	n/a	n/a	n/a	n/a	5.0	30
Merck Sharp & Dohme Corp. US Patent					Assay Description Inhibitor IC50s at purified human autoBACE-2 are determined in a time-resolved endpoint proteolysis assay that measures hydrolysis of the QSY7-EISEVN...				US Patent US9499502 (2016) BindingDB Entry DOI: 10.7270/Q2BV7FJJ
					More data for this Ligand-Target Pair