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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Beta-secretase 2' and Ligand = 'BDBM477890'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-secretase 2


(Homo sapiens (Human))		BDBM477890
PNG
(US10889579, Example 110)
Show SMILES C[C@]1(C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2ccc(cn2)C#N)ccc1F)C(=O)N1CCOCC1 |t:5|
Show InChI InChI=1S/C25H25F2N5O2S/c1-24(15-25(2,35-23(29)31-24)22(33)32-7-9-34-10-8-32)18-11-16(3-5-19(18)26)12-20(27)21-6-4-17(13-28)14-30-21/h3-6,11-12,14H,7-10,15H2,1-2H3,(H2,29,31)/b20-12-/t24-,25-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 130n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...

US Patent US10889579 (2021)


BindingDB Entry DOI: 10.7270/Q241715H
More data for this
Ligand-Target Pair