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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM50528952'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional dihydrofolate reductase-thymidylate synthase


(Cryptosporidium hominis)		BDBM50528952
PNG
(CHEMBL4567826)
Show SMILES COc1cc(cc(c1)-c1ccc(Cc2c[nH]c3nc(N)[nH]c(=O)c23)cc1)C(O)=O
Show InChI InChI=1S/C21H18N4O4/c1-29-16-8-13(7-14(9-16)20(27)28)12-4-2-11(3-5-12)6-15-10-23-18-17(15)19(26)25-21(22)24-18/h2-5,7-10H,6H2,1H3,(H,27,28)(H4,22,23,24,25,26)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as subst...

Eur J Med Chem 183: (2019)


Article DOI: 10.1016/j.ejmech.2019.111673
BindingDB Entry DOI: 10.7270/Q29Z98B8
More data for this
Ligand-Target Pair