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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional dihydrofolate reductase-thymidylate synthase' and Ligand = 'BDBM50528955'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional dihydrofolate reductase-thymidylate synthase


(Cryptosporidium hominis)		BDBM50528955
PNG
(CHEMBL4445309)
Show SMILES Nc1nc2[nH]cc(Cc3ccc(cc3)C(=O)Nc3ccccc3-c3nnn[nH]3)c2c(=O)[nH]1
Show InChI InChI=1S/C21H17N9O2/c22-21-25-18-16(20(32)26-21)13(10-23-18)9-11-5-7-12(8-6-11)19(31)24-15-4-2-1-3-14(15)17-27-29-30-28-17/h1-8,10H,9H2,(H,24,31)(H,27,28,29,30)(H4,22,23,25,26,32)
PDB
MMDB

KEGG

UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.59E+5n/an/an/an/an/an/a



Yale University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Cryptosporidium hominis TS-DHFR expresssed in Escherichia coli PA414 using dUMP and 5,10-methylenetetrahydrofolate as subst...

Eur J Med Chem 183: (2019)


Article DOI: 10.1016/j.ejmech.2019.111673
BindingDB Entry DOI: 10.7270/Q29Z98B8
More data for this
Ligand-Target Pair