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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial' and Ligand = 'BDBM50535657'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial


(Homo sapiens (Human))		BDBM50535657
PNG
(CHEMBL4469262)
Show SMILES OC(=O)c1ccc(cc1)C(=O)N1CCc2c(C1)c(=O)n1CCCn21
Show InChI InChI=1S/C17H17N3O4/c21-15(11-2-4-12(5-3-11)17(23)24)18-9-6-14-13(10-18)16(22)20-8-1-7-19(14)20/h2-5H,1,6-10H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.60E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...

ACS Med Chem Lett 10: 893-898 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00069
BindingDB Entry DOI: 10.7270/Q2J67MFK
More data for this
Ligand-Target Pair