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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial' and Ligand = 'BDBM50535673'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial


(Homo sapiens (Human))		BDBM50535673
PNG
(CHEMBL4517616)
Show SMILES O=C(N1CCc2nc([nH]c(=O)c2C1)-c1ccccc1)c1ccc(cc1)-c1noc(=O)[nH]1
Show InChI InChI=1S/C22H17N5O4/c28-20-16-12-27(11-10-17(16)23-18(24-20)13-4-2-1-3-5-13)21(29)15-8-6-14(7-9-15)19-25-22(30)31-26-19/h1-9H,10-12H2,(H,23,24,28)(H,25,26,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...

ACS Med Chem Lett 10: 893-898 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00069
BindingDB Entry DOI: 10.7270/Q2J67MFK
More data for this
Ligand-Target Pair