Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM22588 (Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 150 | -38.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
The Scripps Research Institute | Assay Description The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ... | J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM22588 (Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | >1.00E+5 | >-22.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Scripps Research Institute | Assay Description Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo... | J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) |