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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bile salt export pump' and Ligand = 'BDBM50239989'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bile salt export pump


(Homo sapiens (Human))		BDBM50239989
PNG
(CHEMBL4086948)
Show SMILES CN1CCN(CC1)c1ccc2ncn(-c3cc(NC(=O)c4cccc(c4)-c4ccco4)ccc3C)c(=O)c2c1
Show InChI InChI=1S/C31H29N5O3/c1-21-8-9-24(33-30(37)23-6-3-5-22(17-23)29-7-4-16-39-29)18-28(21)36-20-32-27-11-10-25(19-26(27)31(36)38)35-14-12-34(2)13-15-35/h3-11,16-20H,12-15H2,1-2H3,(H,33,37)
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Similars
Article
PubMed
n/an/a<1.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...

Drug Metab Dispos 40: 2332-41 (2012)


Article DOI: 10.1124/dmd.112.047068
BindingDB Entry DOI: 10.7270/Q2ZP488M
More data for this
Ligand-Target Pair