Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50443232![]() (CHEMBL3086883) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD1 after 1 hr by fluorescence anisotropy assay | J Med Chem 56: 9251-64 (2013) Article DOI: 10.1021/jm401334s BindingDB Entry DOI: 10.7270/Q2ZW1NCF | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50443232![]() (CHEMBL3086883) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | <85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human 6x-His-tagged BRD4 bromodomain 1 expressed in Escherichia coli | J Med Chem 61: 9316-9334 (2018) Article DOI: 10.1021/acs.jmedchem.8b01248 BindingDB Entry DOI: 10.7270/Q25T3PRQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50443232![]() (CHEMBL3086883) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of human 6x-His-tagged BRD4 bromodomain 2 expressed in Escherichia coli | J Med Chem 61: 9316-9334 (2018) Article DOI: 10.1021/acs.jmedchem.8b01248 BindingDB Entry DOI: 10.7270/Q25T3PRQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50443232![]() (CHEMBL3086883) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Displacement of fluorescein-labeled MS574 from recombinant human BRD4 BrD2 after 1 hr by fluorescence anisotropy assay | J Med Chem 56: 9251-64 (2013) Article DOI: 10.1021/jm401334s BindingDB Entry DOI: 10.7270/Q2ZW1NCF | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (Mus musculus) | BDBM50443232![]() (CHEMBL3086883) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated nitric oxide production preincubated for 30 mi... | J Med Chem 56: 9251-64 (2013) Article DOI: 10.1021/jm401334s BindingDB Entry DOI: 10.7270/Q2ZW1NCF | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Bromodomain-containing protein 4 (Mus musculus) | BDBM50443232![]() (CHEMBL3086883) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Inhibition of BRD4 in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB-mediated IL-6 expression preincubated for 30 mins follo... | J Med Chem 56: 9251-64 (2013) Article DOI: 10.1021/jm401334s BindingDB Entry DOI: 10.7270/Q2ZW1NCF | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |