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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [42-168]' and Ligand = 'BDBM209486'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4 [42-168]


(Homo sapiens (Human))		BDBM209486
PNG
(US10328074, Example III-27 | US11077107, Example I...)
Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1
Show InChI InChI=1S/C25H28N10O/c1-16(2)28-23-25-32-31-17(3)34(25)15-20(29-23)24-30-19-13-27-22(33-8-10-36-11-9-33)12-21(19)35(24)14-18-6-4-5-7-26-18/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,28,29)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Duquesne University



Assay Description
This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...

Bioorg Med Chem 17: 7324-36 (2009)


BindingDB Entry DOI: 10.7270/Q20Z75M2
More data for this
Ligand-Target Pair