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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [42-168]' and Ligand = 'BDBM209491'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4 [42-168]


(Homo sapiens (Human))		BDBM209491
PNG
(US10328074, Example III-32 | US11077107, Example I...)
Show SMILES CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N(C)C
Show InChI InChI=1S/C24H27N9/c1-15(2)26-22-24-30-29-16(3)32(24)14-20(27-22)23-28-19-10-9-18(31(4)5)12-21(19)33(23)13-17-8-6-7-11-25-17/h6-12,14-15H,13H2,1-5H3,(H,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Duquesne University



Assay Description
This assay is used to determine whether the compounds inhibit the interaction between the first (BRD4-BD1) or the second (BRD4-BD2) bromodomain of BR...

Bioorg Med Chem 17: 7324-36 (2009)


BindingDB Entry DOI: 10.7270/Q20Z75M2
More data for this
Ligand-Target Pair