Found 2 hits Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [42-168]' and Ligand = 'BDBM362673' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bromodomain-containing protein 4 [42-168]
(Homo sapiens (Human)) | BDBM362673
![PNG](/data/jpeg/tenK36/BindingDB_362673.png) ((4S)-2-[4-(cyclobutylcarbonyl)piperazin-1- yl]-7-(...)Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN(CC3)C(=O)C3CCC3)n3[C@H](COc1c23)c1ccccn1 |wD:26.36,(.39,-5.61,;1.85,-6.08,;2.33,-7.55,;3.87,-7.55,;4.34,-6.08,;5.81,-5.61,;3.1,-5.18,;3.1,-3.64,;4.43,-2.87,;4.43,-1.33,;3.1,-.56,;2.53,.88,;.99,.88,;.22,2.21,;-1.32,2.21,;-2.09,3.55,;-1.32,4.88,;.22,4.88,;.99,3.55,;-2.09,6.21,;-1.32,7.55,;-3.63,6.21,;-4.72,5.12,;-5.81,6.21,;-4.72,7.3,;.43,-.56,;-.9,-1.33,;-.9,-2.87,;.43,-3.64,;1.76,-2.87,;1.76,-1.33,;-2.24,-.56,;-3.57,-1.33,;-4.91,-.56,;-4.91,.98,;-3.57,1.75,;-2.24,.98,)| Show InChI InChI=1S/C28H30N6O3/c1-17-24(18(2)37-31-17)20-9-10-22-25-26(20)36-16-23(21-8-3-4-11-29-21)34(25)28(30-22)33-14-12-32(13-15-33)27(35)19-6-5-7-19/h3-4,8-11,19,23H,5-7,12-16H2,1-2H3/t23-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <25 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
US Patent
| Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib... |
US Patent US9834565 (2017)
BindingDB Entry DOI: 10.7270/Q29P33XS |
More data for this Ligand-Target Pair | |
Bromodomain-containing protein 4 [42-168]
(Homo sapiens (Human)) | BDBM362673
![PNG](/data/jpeg/tenK36/BindingDB_362673.png) ((4S)-2-[4-(cyclobutylcarbonyl)piperazin-1- yl]-7-(...)Show SMILES Cc1noc(C)c1-c1ccc2nc(N3CCN(CC3)C(=O)C3CCC3)n3[C@H](COc1c23)c1ccccn1 |wD:26.36,(.39,-5.61,;1.85,-6.08,;2.33,-7.55,;3.87,-7.55,;4.34,-6.08,;5.81,-5.61,;3.1,-5.18,;3.1,-3.64,;4.43,-2.87,;4.43,-1.33,;3.1,-.56,;2.53,.88,;.99,.88,;.22,2.21,;-1.32,2.21,;-2.09,3.55,;-1.32,4.88,;.22,4.88,;.99,3.55,;-2.09,6.21,;-1.32,7.55,;-3.63,6.21,;-4.72,5.12,;-5.81,6.21,;-4.72,7.3,;.43,-.56,;-.9,-1.33,;-.9,-2.87,;.43,-3.64,;1.76,-2.87,;1.76,-1.33,;-2.24,-.56,;-3.57,-1.33,;-4.91,-.56,;-4.91,.98,;-3.57,1.75,;-2.24,.98,)| Show InChI InChI=1S/C28H30N6O3/c1-17-24(18(2)37-31-17)20-9-10-22-25-26(20)36-16-23(21-8-3-4-11-29-21)34(25)28(30-22)33-14-12-32(13-15-33)27(35)19-6-5-7-19/h3-4,8-11,19,23H,5-7,12-16H2,1-2H3/t23-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <25 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
| Assay Description BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib... |
J Med Chem 51: 1904-12 (2008)
BindingDB Entry DOI: 10.7270/Q2D50Q7W |
More data for this Ligand-Target Pair | |