Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon' and Ligand = 'BDBM511634'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human))	BDBM511634 (US11059801, Compound dBET43) Show SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCC(=O)Nc1cccc3C(=O)N(Cc13)C1CCC(=O)NC1=O)c1nnc(C)n-21)c1ccc(Cl)cc1 |r,c:8| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-...				Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM
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